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KMID : 0043320110340030383
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Archives of Pharmacal Research
2011 Volume.34 No. 3 p.383 ~ p.389
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Chemical constituents of the leaves of Glochidion obliquum and their bioactivity
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Thang Tran Dinh
Kuo Ping Chung
Yu Chun-Shu
Shen Yuh-Chiang
Hoa Le Thi Mai
Thanh Tran Van
Kuo Yao-Haur
Yang Mei-Lin
Wu Tian-Shung
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Abstract
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A new flavonoid glycoside, globlin A (1), and eleven known compounds were isolated from methanolic extracts of the leaves of Glochidion obliquum. The structure of this new compound was established with a combination of 2D NMR techniques (COSY, NOESY, HMQC and HMBC) and HR-ESI-MS analyses. Chemical structures of the other known compounds were identified by comparison of their spectroscopic and physical data with those reported in the literature. Some of the isolates were examined for their bioactivities. Among the tested compounds, rotundic acid (4) displayed significant cytotoxicity and anti-inflammatory activities.
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KEYWORD
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Flavonoid glycoside, Euphorbiaceae, Cytotoxicity, Anti-inflammatory, DPPH
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