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KMID : 0043320120350020197
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Archives of Pharmacal Research
2012 Volume.35 No. 2 p.197 ~ p.200
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Multi-targeted hybrids based on HDAC inhibitors for anti-cancer drug discovery
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Seo Seung-Yong
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Abstract
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Multi-targeted hybrids combine two drugs in a single molecule to have greater medicinal effects than its individual components. Recently, a number of anti-cancer drug candidates such as CUDC-101 (Curis) have been designed based on linking properly two selected pharmacophores endowed with activity against different therapeutic targets.
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