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KMID : 0043320120350081387
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Archives of Pharmacal Research
2012 Volume.35 No. 8 p.1387 ~ p.1392
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Antimicrobial aflatoxins from the marine-derived fungus Aspergillus flavus 092008
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Wang Hui
Lu Zhenyu
Qu Hai Jun
Liu Peipei
Miao Chengdu
Zhu Tonghan
Li Jing
Hong Kui
Zhu Weiming
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Abstract
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A new aflatoxin, aflatoxin B2b (1), together with six known compounds, were isolated from the marine-derived fungus Aspergillus flavus 092008 endogenous with the mangrove plant Hibiscus tiliaceus (Malvaceae). The structure of 1 was determined by the spectroscopic and chemical methods. Compound 1 exhibited a moderate antimicrobial activity against Escherichia coli, Bacillus subtilis and Enterobacter aerogenes, with MIC values of 22.5, 1.7 and 1.1 M, respectively. Compound 1 also showed a weak cytotoxicity against A549, K562 and L-02 cell lines, with IC50 values of 8.1, 2.0 and 4.2 M, respectively. The results showed that hydration and hydrogenation of 8-double bond significantly reduces the cytotoxicity of aflatoxins, while the esterification at C-8 increases the cytotoxicity.
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KEYWORD
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Aflatoxinb, Antibacterial activity, Aspergillus flavus, Cytotoxicity, Mangrove plant
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