|
KMID : 0043320130360070832
|
|
Archives of Pharmacal Research
2013 Volume.36 No. 7 p.832 ~ p.839
|
|
|
Synthesis of novel derivatives of murrayafoline A and their inhibitory effect on LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells
|
|
Thuy Tran Thi Thu
Cuong Nguyen Manh
Manh Cuong Nguyen
Thang Ngo Ngoc
Tai Bui Huu
Nhiem Nguyen Xuan
Hong Hye-Jin
Kim So-Hyun
Legoupy Stephanie
Koh Young-Sang
Kim Young-Ho
|
|
|
Abstract
|
|
|
|
A series of N-substituted-1,2,3-triazole murrayafoline A derivatives were successfully synthesized using click azide?alkyne Huisgen cycloaddition reaction between 1-methoxy-3-methyl-9-(3-azido)-propyl-9H-carbazole and substituted alkynes. Their chemical structures were confirmed by 1H, 13C NMR and HR-ESI?MS spectral data. In addition, the interested effects on LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells of synthetic murrayafoline A derivatives were also investigated. Our results indicated that murrayafoline A derivatives containing 1,2,3-triazole nucleus potentially possessed anti-inflammatory action through inhibiting production of IL-6, IL-12 p40 and TNF-α.
|
|
|
KEYWORD
|
|
|
Murrayafoline A, 1, 2, 3-triazole, TNF-α, IL-6, IL-12 p40
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|