KMID : 0043320130360111311
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Archives of Pharmacal Research 2013 Volume.36 No. 11 p.1311 ~ p.1318
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Simultaneous determination of five flavonoids during the growth of Fructus Sophorae by capillary electrophoresis
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Li Yu Mei
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Abstract
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A method of simultaneous determination of five flavonoids during the growth of Fructus Sophorae by ¥â-cyclodextrin (¥â-CD-) modified capillary zone electrophoresis was developed. The effects of various parameters such as buffer concentration, pH, applied voltage, and ¥â-CD concentrations were investigated. After a series of optimization processes, the determination of five flavonoids in Fructus Sophorae was successfully achieved in 20 mmol/L borax buffer (pH 9.5), 25 kV applied voltage, and 8 mmol/L ¥â-CD. The linearity, detection limits, repeatability, and recovery were satisfactory. Thus, the proposed ¥â-CD-modified capillary zone electrophoresis method was satisfactorily used to analyze Fructus Sophorae samples. The results can be useful for the quality control and medicinal resource development of Fructus Sophorae.
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KEYWORD
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Fructus Sophorae, Flavonoids, ¥â-cyclodextrin-modified capillary zone electrophoresis
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