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KMID : 0043320130360111311
Archives of Pharmacal Research
2013 Volume.36 No. 11 p.1311 ~ p.1318
Simultaneous determination of five flavonoids during the growth of Fructus Sophorae by capillary electrophoresis
Li Yu Mei

Abstract
A method of simultaneous determination of five flavonoids during the growth of Fructus Sophorae by ¥â-cyclodextrin (¥â-CD-) modified capillary zone electrophoresis was developed. The effects of various parameters such as buffer concentration, pH, applied voltage, and ¥â-CD concentrations were investigated. After a series of optimization processes, the determination of five flavonoids in Fructus Sophorae was successfully achieved in 20 mmol/L borax buffer (pH 9.5), 25 kV applied voltage, and 8 mmol/L ¥â-CD. The linearity, detection limits, repeatability, and recovery were satisfactory. Thus, the proposed ¥â-CD-modified capillary zone electrophoresis method was satisfactorily used to analyze Fructus Sophorae samples. The results can be useful for the quality control and medicinal resource development of Fructus Sophorae.
KEYWORD
Fructus Sophorae, Flavonoids, ¥â-cyclodextrin-modified capillary zone electrophoresis
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