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KMID : 0043320130360111319
Archives of Pharmacal Research
2013 Volume.36 No. 11 p.1319 ~ p.1325
Five new sesquiterpene lactones from Inula hupehensis
Ren Jie

Qin Jiang Jiang
Cheng Xiang Rong
Yan Shi Kai
Jin Hui Zi
Zhang Wei Dong
Abstract
Four new pseudoguaianolides (1?4), one new guaianolide (5), together with ten known compounds (6?15) were isolated from the aerial parts of Inula hupehensis. Their structures were elucidated mainly on the basis of 1D and 2D spectroscopic methods and circular dichroism analysis. In addition, compounds 1?10 and 13 were tested for their inhibitory effects against LPS-induced NO production in RAW264.7 macrophages. Compounds 2, 6, 8 and 9 exhibited significant inhibitory activities with IC50 values in the range of 0.6?6.6 ¥ìM.
KEYWORD
Inula hupehensis, Pseudoguaianolide, Guaianolide, NO production
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