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KMID : 0043320130360111319
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Archives of Pharmacal Research
2013 Volume.36 No. 11 p.1319 ~ p.1325
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Five new sesquiterpene lactones from Inula hupehensis
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Ren Jie
Qin Jiang Jiang
Cheng Xiang Rong
Yan Shi Kai
Jin Hui Zi
Zhang Wei Dong
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Abstract
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Four new pseudoguaianolides (1?4), one new guaianolide (5), together with ten known compounds (6?15) were isolated from the aerial parts of Inula hupehensis. Their structures were elucidated mainly on the basis of 1D and 2D spectroscopic methods and circular dichroism analysis. In addition, compounds 1?10 and 13 were tested for their inhibitory effects against LPS-induced NO production in RAW264.7 macrophages. Compounds 2, 6, 8 and 9 exhibited significant inhibitory activities with IC50 values in the range of 0.6?6.6 μM.
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KEYWORD
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Inula hupehensis, Pseudoguaianolide, Guaianolide, NO production
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