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KMID : 0043320150380071281
Archives of Pharmacal Research
2015 Volume.38 No. 7 p.1281 ~ p.1298
Interactions between herbs and antidiabetics: an overview of the mechanisms, evidence, importance, and management
Rehman Shaheed Ur

Choi Min-Sun
Choe Kevin
Yoo Hye-Hyun
Abstract
Complementary and alternative therapies are quickly gaining importance because they are perceived to be free of side effects due to their natural origin. However, herbal remedies are complex mixtures of bioactive entities, which may interact with prescription drugs through pharmacokinetic or pharmacodynamic mechanisms and sometimes result in life-threatening consequences. In particular, diabetes patients are often treated with multiple medications due to different comorbidities, and such patients use antidiabetic medications for their entire lives; thus, it is important to make the public aware of herb interactions with antidiabetic drugs. In this paper, we summarize the reports available on the interaction of herbal remedies with oral hypoglycemic agents and describe mechanisms, preclinical or clinical evidence, importance, and management strategies.
KEYWORD
Herb?drug interaction, Antidiabetics, Mechanism, Evidence, Management
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