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KMID : 0043320150380081449
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Archives of Pharmacal Research
2015 Volume.38 No. 8 p.1449 ~ p.1454
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Penipyrols A?B and peniamidones A?D from the mangrove derived Penicillium solitum GWQ-143
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Guo Wenqiang
Kong Xianglan
Zhu Tianjiao
Gu Qianqun
Li Dehai
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Abstract
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Chemical investigation the extract of Penicilliumsolitum GWQ-143 led to yield four new compounds penipyrols A?B (1?2) and peniamidones A?B (3?4), together with peniamidones C?D (5?6), which had been previously described as synthetic intermediates, not obtained from natural resource. The structures of those new compounds were established through extensive spectroscopic analysis. Compounds 1?6 exhibited great radical scavenging activities against DPPH with IC50 values ranged from 4.7 to 15.0 μM.
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KEYWORD
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Mangrove, Penicillium solitum, Penipyrol, Peniamidone, Radical scavenging activity
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