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KMID : 0043320160390010127
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Archives of Pharmacal Research
2016 Volume.39 No. 1 p.127 ~ p.132
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Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells
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Jang Ha-Ri
Lee Jin-Woo
Lee Chul
Jin Qinghao
Choi Jeong-Yeon
Lee Dong-Ho
Han Sang-Bae
Kim Young-Soo
Hong Jin-Tae
Lee Mi-Kyeong
Hwang Bang-Yeon
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Abstract
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A new oplopane-type sesquiterpenoid tussilagofarin (1) and a new chromone tussilagofarol (2), along with 18 known compounds 3?20, were isolated from the flower buds of Tussilago farfara. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR and HRESIMS data. Of the isolated compounds, oplopane- and bisabolane-type sesquterpenoids 1, 8?12, 15, and 16 were found to inhibit nitric oxide production in LPS-induced RAW 264.7 cells with IC50 values of 3.5?28.5 μM.
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KEYWORD
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Tussilago farfara, Asteraceae, Oplopane-type sesquiterpenoid, Nitric oxide production inhibitor
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