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KMID : 0043320160390020172
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Archives of Pharmacal Research
2016 Volume.39 No. 2 p.172 ~ p.177
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Xanthones from Garcinia paucinervis with in vitro anti-proliferative activity against HL-60 cells
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Li Da Hong
Li Chen Xi
Jia Cui Cui
Sun Ya Ting
Xue Chun Mei
Bai Jiao
Hua Hui Ming
Liu Xiao Qiu
Li Zhan Lin
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Abstract
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Three new xanthones, paucinervins H?J (1?3), as well as eleven known compounds (4?14), were isolated from the leaves of Garcinia paucinervis. The structures of the new compounds (1?3) were elucidated by 1D, 2D NMR spectra and HR ESIMS. In vitro antiproliferative activity against human promyelocytic leukemia HL-60 cells was tested, among which, compounds 2, 5, 6 and 7 exhibited strong growth inhibitory effects with GI50 values ranging from 1.30 to 9.08 μM, respectively. Preliminary SARs were also discussed.
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KEYWORD
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Garcinia paucinervisGuttiferaeXanthoneCytotoxic activity
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