Àá½Ã¸¸ ±â´Ù·Á ÁÖ¼¼¿ä. ·ÎµùÁßÀÔ´Ï´Ù.
KMID : 0043320160390101349
Archives of Pharmacal Research
2016 Volume.39 No. 10 p.1349 ~ p.1355
Synthesis of biscoumarin and dihydropyran derivatives as two novel classes of potential anti-bacterial derivatives
Li Jing

Xue Xiao yan
Li Xia
Hou Zheng
Yang Xiao hui
Qu Di
Zhou Ying
Zhang Zi dan
Luo Xiao xing
Li Jiang tao
Li Ming kai
Abstract
A series of bisoumarin (1?4) and dihydropyran (5?8) derivatives were successfully synthesized as new antibacterial agents. The molecular structures of three representative compounds 1, 5 and 7 were confirmed by single crystal X-ray diffraction study. Among these compounds tested toward Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), and USA 300 (Los Angeles County clone, LAC), compounds 1 and 2 displayed the most potent antibacterial activity. Additionally, the HB energy in biscoumarins 1?4 was calculated by density functional theory (DFT) [B3LYP/6-31G*] method.
KEYWORD
Bisoumarin, Dihydropyran, Antibacterial, DFT
FullTexts / Linksout information
Listed journal information
SCI(E) MEDLINE ÇмúÁøÈïÀç´Ü(KCI)