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KMID : 0043320160390101349
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Archives of Pharmacal Research
2016 Volume.39 No. 10 p.1349 ~ p.1355
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Synthesis of biscoumarin and dihydropyran derivatives as two novel classes of potential anti-bacterial derivatives
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Li Jing
Xue Xiao yan
Li Xia
Hou Zheng
Yang Xiao hui
Qu Di
Zhou Ying
Zhang Zi dan
Luo Xiao xing
Li Jiang tao
Li Ming kai
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Abstract
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A series of bisoumarin (1?4) and dihydropyran (5?8) derivatives were successfully synthesized as new antibacterial agents. The molecular structures of three representative compounds 1, 5 and 7 were confirmed by single crystal X-ray diffraction study. Among these compounds tested toward Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), and USA 300 (Los Angeles County clone, LAC), compounds 1 and 2 displayed the most potent antibacterial activity. Additionally, the HB energy in biscoumarins 1?4 was calculated by density functional theory (DFT) [B3LYP/6-31G*] method.
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KEYWORD
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Bisoumarin, Dihydropyran, Antibacterial, DFT
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