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KMID : 0043320160390111537
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Archives of Pharmacal Research
2016 Volume.39 No. 11 p.1537 ~ p.1547
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Targeting IL-17 in autoimmunity and inflammation
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Kim Byung-Seok
Park Young-Jun
Chung Yeon-Seok
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Abstract
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The discovery of two distinct subsets of helper T cells, IFN-γ-producing Th1 cells and IL-4-producing Th2 cells, about three decades ago enabled us to understand the immunopathology of cell-mediated and allergic inflammatory diseases in humans. The observation that T cell-mediated experimental autoimmune diseases can be induced in mice lacking Th1 and Th2 cell responses prompted many immunologists to hypothesize that there might be additional subsets in helper T cell population which mediate autoimmunity in the absence of Th1 and Th2 cells. Consequently, multiple independent research groups identified IL-17-expressing RORγt+CD4+ T cell population as a distinct subset of helper T cells which promotes autoimmune tissue inflammation. Subsequent studies have revealed that innate immune cells, including γδ T cells, NKT cells and innate lymphoid cells, also produce type 17 cytokines and contribute to tissue inflammation. In this review, we discuss our current understanding on the biology of IL-17 and the therapeutic potential of targeting IL-17 for the treatment of immune disorders in humans.
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KEYWORD
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IL-17, Th17 cell, Autoimmunity, Anti-IL-17, RORγt
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