|
KMID : 0043320230460020117
|
|
Archives of Pharmacal Research
2023 Volume.46 No. 2 p.117 ~ p.130
|
|
|
Dapagliflozin attenuates myocardial remodeling in hypertension by activating the circadian rhythm signaling pathway
|
|
Wang Jing
She Qiang
Du Jianlin
|
|
|
Abstract
|
|
|
|
Sodium-glucose cotransporter 2 inhibitor (SGLT2i) is a new kind of antidiabetic drug which has shown beneficial effects in reducing heart failure-related hospitalization and cardiovascular-related mortality. The mechanisms are complicated. Our study aimed to investigate the effects of dapagliflozin on the myocardium of spontaneously hypertensive rats (SHRs) without heart failure. Wistar-Kyoto rats were used as normal controls. SHRs were randomly divided into the SHR group and the -treated group. After 8 weeks of dapagliflozin treatment, the morphology of heart tissues was examined. The mRNA expression profiles were identified via RNA sequencing (RNA-Seq). Various analysis methods were used to find the differentially expressed genes (DEGs) to predict gene function and coexpression. After dapagliflozin treatment, systolic blood pressure was significantly reduced compared with that in the SHR group. Myocardial remodeling was ameliorated compared with that in the SHR group. After dapagliflozin intervention, 75 DEGs (|log2-fold change | > 0 and Q value?
|
|
|
KEYWORD
|
|
|
SGLT2i , Spontaneous hypertensive rats , Wistar?Kyoto rats , Circadian rhythm signaling pathway , Transcriptomic
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|