|
KMID : 0191120100250111601
|
|
Journal of Korean Medical Science
2010 Volume.25 No. 11 p.1601 ~ p.1608
|
|
|
Clinical Benefit of Low Molecular Weight Heparin for ST-segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention with Glycoprotein IIb/IIIa Inhibitor
|
|
Cho Jung-Sun
Her Sung-Ho
Baek Ju-Yeal
Park Mahn-Won
Kim Hyoung-Doo
Jeong Myung-Ho
Ahn Young-Keun
Chae Shung-Chull
Hur Seung-Ho
Hong Taek-Jong
Kim Young-Jo
Seong In-Whan
Chae Jei-Keon
Rhew Jay-Young
Chae In-Ho
Cho Myeong-Chan
Bae Jang-Ho
Rha Seung-Woon
Kim Chong-Jim
Choi Dong-Hoon
Jang Yang-Soo
Yoon Jung-Han
Chung Wook-Sung
Cho Jeong-Gwan
Seung Ki-Bae
Park Seung-Jung
|
|
|
Abstract
|
|
|
|
The efficacy of low molecular weight heparin (LMWH) with low dose unfractionated heparin (UFH) during percutaneous coronary intervention (PCI) with or without glycoprotein (Gp) IIb/IIIa inhibitor compared to UFH with or without Gp IIb/IIIa inhibitor has not been elucidated. Between October 2005 and July 2007, 2,535 patients with ST elevation acute myocardial infarction (STEMI) undergoing PCI in the Korean Acute Myocardial Infarction Registry (KAMIR) were assigned to either of two groups: a group with Gp IIb/IIIa inhibitor (n=476) or a group without Gp IIb/IIIa inhibitor (n=2,059). These groups were further subdivided according to the use of LMWH with low dose UFH (n=219) or UFH alone (n=257). The primary end points were cardiac death or myocardial infarction during the 30 days after the registration. The primary end point occurred in 4.1% (9/219) of patients managed with LMWH during PCI and Gp IIb/IIIa inhibitor and 10.8% (28/257) of patients managed with UFH and Gp IIb/IIIa inhibitor (odds ratio [OR], 0.290; 95% confidence interval [CI], 0.132-0.634; P=0.006). Thrombolysis In Myocardial Infarction (TIMI) with major bleeding was observed in LMHW and UFH with Gp IIb/IIIa inhibitor (1/219 [0.5%] vs 1/257 [0.4%], P=1.00). For patients with STEMI managed with a primary PCI and Gp IIb/IIIa inhibitor, LMWH is more beneficial than UFH.
|
|
|
KEYWORD
|
|
|
Myocardial Infarction, Heparin, Blood Platelets, Prognosis
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
    
|