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KMID : 0191120130280111609
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Journal of Korean Medical Science
2013 Volume.28 No. 11 p.1609 ~ p.1614
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A Prospective, Randomized Comparison of Promus Everolimus-Eluting and TAXUS Liberte Paclitaxel-Eluting Stent Systems in Patients with Coronary Artery Disease Eligible for Percutaneous Coronary Intervention: The PROMISE Study
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Kim Ung
Lee Chan-Hee
Jo Jung-Hwan
Lee Hyun-Wook
Choi Yoon-Jung
Son Jang-Won
Lee Sang-Hee
Park Jong-Seon
Shin Dong-Gu
Kim Young-Jo
Jeong Myung-Ho
Cho Myung-Chan
Bae Jang-Ho
Lee Jae-Hwan
Kang Tae-Soo
Jung Kyung-Tae
Jung Kyung-Ho
Lee Seung-Wook
Cho Jang-Hyun
Kim Won
Hur Seung-Ho
Kim Ki-Sik
Park Heon-Sik
Kim Moo-Hyun
Hwang Jin-Yong
Kim Doo-Il
Kim Tae-Ik
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Abstract
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We aimed comparing two-year clinical outcomes of the Everolimus-Eluting Promus and Paclitaxel-Eluting TAXUS Liberte stents used in routine clinical practice. Patients with objective evidence of ischemia and coronary artery disease eligible for PCI were prospectively randomized to everolimus-eluting stent (EES) or paclitaxel-eluting stent (PES) groups. The primary end-point was ischemia-driven target vessel revascularization (TVR) at 2 yr after intervention, and the secondary end-point was a major adverse cardiac event (MACE), such as death, myocardial infarction (MI), target lesion revascularization (TLR), TVR or stent thrombosis. A total of 850 patients with 1,039 lesions was randomized to the EES (n=425) and PES (n=425) groups. Ischemic-driven TVR at 2 yr was 3.8% in the PES and 1.2% in the EES group (P for non-inferiority=0.021). MACE rates were significantly different; 5.6% in PES and 2.5% in EES (P = 0.027). Rates of MI (0.8% in PES vs 0.2% in EES, P = 0.308), all deaths (1.5% in PES vs 1.2% in EES, P = 0.739) and stent thrombosis (0.3% in PES vs 0.7% in EES, P = 0.325) were similar. The clinical outcomes of EES are superior to PES, mainly due to a reduction in the rate of ischemia-driven TVR.
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KEYWORD
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Everolimus-Eluting Stent, Paclitaxel-Eluting Stent
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