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KMID : 0191120150300060725
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Journal of Korean Medical Science
2015 Volume.30 No. 6 p.725 ~ p.732
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Prevalence of Spirometrically-defined Restrictive Ventilatory Defect in Korea: The Fourth-2, 3, and Fifth Korean National Health and Nutrition Examination Survey, 2008-2012
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Lee Jung-Yeon
Hwang Yong-Il
Park Yong-Bum
Park Jae-Yong
Kim Ki-Uk
Oh Yeon-Mok
Yoon Hyoung-Kyu
Yoon Ho-Il
Sheen Sueng-Su
Lee Sang-Yeub
Lee Chang-Hoon
Lee Heung-Bum
Lim Sung-Chul
Jung Sung-Soo
Oh Kyung-Won
Kim Yu-Na
Chun Chae-Min
Yoo Kwang-Ha
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Abstract
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The aim of the study was to evaluate the prevalence of restrictive ventilatory defect and to determine the risk factors in subjects with spirometrically-defined restrictive ventilatory defect. We used the population-based, fourth-2, 3 (2008, 2009) and fifth (2010-2012) Korea National Health and Nutrition Examination Survey (KNHANES) to analyze 15,073 subjects, aged ≥40 yr who underwent spirometry. Chest radiographs were also analyzed to identify restrictive lung disease. Spirometrically-defined restrictive ventilatory defect (FEV1/FVC≥70% and FVC<80% of mean predicted value) was detected in 11.3% (n= 1,709) of subjects aged ≥40 yr. The prevalence increased to 12.3% on using the lower limit of normal (LLN) criteria. Approximately 99.4% of subjects were classified as mild restrictive. Among these, 11.3% had inactive tuberculosis (TB) lesion, 2.2% cardiac disease, 2.0% previous operation scar or radiation injury and/or mediastinal disease, and 7.4% other pulmonary disease suggestive of restrictive lung diseases on chest radiograph. Evidence of previous TB history was independently associated with restrictive ventilatory defect (odds ratios [OR], 1.78; 95% confidence interval, 1.45-2.18) after adjustment for gender, age, smoking, area for residence and body mass index. The prevalence of restrictive ventilatory defect among the nationwide population in Korea was 11.3% with fixed ratio criterion and 12.3% with LLN criterion. Most cases were of the mild restrictive category and previous TB history is the independent risk factor for restrictive ventilatory defect.
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KEYWORD
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Epidemiology, Lung Diseases, Interstitial, Respiratory Function Tests, Tuberculosis, X-Rays
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