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KMID : 0191120170320050757
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Journal of Korean Medical Science
2017 Volume.32 No. 5 p.757 ~ p.763
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Effect of Coenzyme Q10 on Radiation Nephropathy in Rats
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Ki Yong-Kan
Kim Won-Taek
Kim Yong-Ho
Kim Dong-Hyun
Bae Jin-Sook
Park Dahl
Jeon Ho-Sang
Lee Ju-Hye
Lee Ja-Young
Nam Ji-Ho
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Abstract
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The kidney is one of the most radiosensitive organs in the abdominal cavity and is the dose-limiting structure in cancer patients receiving abdominal or total body irradiation. In the present study, the effect of coenzyme Q10 (CoQ10) on radiation nephropathy was evaluated in rats. A total of 72 rats were equally randomized into 4 groups: Control, CoQ10, irradiation with 10 Gy (RT) + placebo, or RT + CoQ10. The 2 RT groups received single 10 Gy of abdominal irradiation. The 2 CoQ10 groups were supplemented daily with 1 mL of soybean oil containing 10 mg/kg of CoQ10. The RT + placebo and control groups received same dose of soybean oil. After 24 weeks, laboratory and histopathologic findings were compared. The 2 RT groups showed significant increases in blood urea nitrogen (BUN) and creatinine levels and significant pathologic changes such as glomerulosclerosis and tubulointerstitial fibrosis. CoQ10 supplementation resulted in significant reductions of BUN and creatinine levels compared with the RT + placebo group (P < 0.001 and P = 0.038, respectively). CoQ10 treatment significantly attenuated glomerular and tubular changes of irradiated kidney in semiquantitative analysis (P < 0.001 for both). Administration of CoQ10 can alleviate the radiation-induced nephropathy.
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KEYWORD
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Coenzyme Q10, Radiation Therapy, Total Body Irradiation, Radiation Nephropathy, Rats
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