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KMID : 0191120180330110094
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Journal of Korean Medical Science
2018 Volume.33 No. 11 p.94 ~ p.94
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Diagnostic Performance of %[-2]proPSA and Prostate Health Index for Prostate Cancer: Prospective, Multi-institutional Study
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Park Hong-Zoo
Lee Sang-Wook
Song Gee-Hyun
Kang Tae-Wook
Jung Jae-Hung
Chung Hyun-Chul
Kim Sung-Jin
Park Chang-Hoo
Park Jong-Yeon
Shin Tae-Young
Suh In-Bum
Kim Jeong-Hyun
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Abstract
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Background: We evaluated the clinical performance of [-2]proPSA (p2PSA) and its derivatives in predicting the presence and aggressiveness of prostate cancer (PCa) in Korean men.
Methods: A total of 246 men with total prostate-specific antigen (tPSA) ≥ 3.5 ng/mL who underwent their first prostate biopsy were included in this prospective, multicenter, observational study. Diagnostic accuracy of tPSA, free-to-total PSA ratio (%fPSA), p2PSA, %p2PSA, and the Beckman Coulter prostate health index (PHI) was assessed by receiver operating characteristic curve analyses and logistic regression analyses.
Results: Overall, PCa was detected in 125 (50.8%) subjects. In men with tPSA 3.5?10 ng/mL, the detection rate of PCa was 39.4% (61/155). In this group, PHI and %p2PSA were the most accurate predictors of PCa and significantly outperformed tPSA and %fPSA; area under the curve for tPSA, %fPSA, %p2PSA, and PHI was 0.56, 0.69, 0.74, and 0.76, respectively. PHI was also the strongest predictor of PCa with Gleason score ≥ 7.
Conclusion: This study demonstrates the superior clinical performance of %p2PSA and PHI in predicting the presence and aggressiveness of PCa in Korean men. The %p2PSA and PHI appear to improve detection of PCa and provide prognostic information.
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KEYWORD
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Biomarkers, Biopsy, Early Diagnosis, Prostatic Cancer, Prostate-specific Antigen
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