|
KMID : 0191120180330520346
|
|
Journal of Korean Medical Science
2018 Volume.33 No. 52 p.346 ~ p.346
|
|
|
Treat-to-Target Strategy for Asian Patients with Early Rheumatoid Arthritis: Result of a Multicenter Trial in Korea
|
|
Song Jason Jung-Sik
Song Yeong-Wook
Bae Sang-Cheol
Cha Hoon-Suk
Choe Jung-Yoon
Choi Sung-Jae
Kim Hyun-Ah
Kim Jin-Seok
Kim Sung-Soo
Lee Choong-Ki
Lee Ji-Soo
Lee Sang-Heon
Lee Shin-Seok
Lee Soo-Kon
Lee Sung-Won
Park Sung-Hwan
Park Won
Shim Seung-Cheol
Suh Chang-Hee
Yoo Bin
Yoo Dae-Hyun
Yoo Wan-Hee
|
|
|
Abstract
|
|
|
Background: To evaluate the therapeutic benefits of the treat-to-target (T2T) strategy for Asian patients with early rheumatoid arthritis (RA) in Korea.
Methods: In a 1-year, multicenter, open-label strategy trial, 346 patients with early RA were recruited from 20 institutions across Korea and stratified into 2 groups, depending on whether they were recruited by rheumatologists who have adopted the T2T strategy (T2T group) or by rheumatologists who provided usual care (non-T2T group). Data regarding demographics, rheumatoid factor titer, anti-cyclic citrullinated peptide antibody titer, disease activity score of 28 joints (DAS28), and Korean Health Assessment Questionnaire (KHAQ) score were obtained at baseline and after 1 year of treatment. In the T2T group, the prescription for disease-modifying antirheumatic drugs was tailored to the predefined treatment target in each patient, namely remission (DAS28 < 2.6) or low disease activity (LDA) (2.6 ≤ DAS28 < 3.2).
Results: Data were available for 163 T2T patients and 162 non-T2T patients. At the end of the study period, clinical outcomes were better in the T2T group than in the non-T2T group (LDA or remission, 59.5% vs. 35.8%; P < 0.001; remission, 43.6% vs. 19.8%; P < 0.001). Compared with non-T2T, T2T was also associated with higher rate of good European League Against Rheumatism response (63.0% vs. 39.8%; P < 0.001), improved KHAQ scores (?0.38 vs. ?0.13; P = 0.008), and higher frequency of follow-up visits (5.0 vs. 2.0 visits/year; P < 0.001).
Conclusion: In Asian patients with early RA, T2T improves disease activity and physical function. Setting a pre-defined treatment target in terms of DAS28 is recommended.
|
|
|
KEYWORD
|
|
|
Rheumatoid Arthritis, Treatment Outcome, Treat-to-target
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|
|