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KMID : 0191120200350220164
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Journal of Korean Medical Science
2020 Volume.35 No. 22 p.164 ~ p.164
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Nonalcoholic Fatty Liver Disease Is Associated with Benign Prostate Hyperplasia
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Chung Goh-Eun
Yim Jeong-Yoon
Kim Dong-Hee
Kwak Min-Sun
Yang Jong-In
Park Bo-Ram
An Seong-Joon
Kim Joo-Sung
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Abstract
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Background: Nonalcoholic fatty liver disease (NAFLD) is associated with a wide spectrum of metabolic abnormalities. This study aimed to evaluate whether NAFLD is associated with benign prostatic hyperplasia (BPH) independent of other risk factors.
Methods: A total of 3,508 subjects who underwent prostate and hepatic ultrasonography were enrolled. NAFLD was diagnosed and graded by ultrasonographic findings. BPH was defined by total prostate volume.
Results: The prevalence of BPH was significantly increased according to NAFLD severity (P < 0.001). The multivariate analysis showed that NAFLD was associated with a 22% increase in the risk of BPH (odds ratio [OR], 1.22; 95% confidence interval [CI], 1.02?1.45). In non-obese subjects, NAFLD was associated with a 41% increase in the risk of BPH (OR, 1.41; 95% CI, 1.14?1.73), and an incremental increase in the risk of BPH according to NAFLD severity was pronounced (adjusted OR [95% CI], 1.32 [1.05?1.68] for mild NAFLD, 1.55 [1.15?2.10] for moderate to severe NAFLD vs. no NAFLD, P for trend = 0.004). However, in the obese population, the association of NAFLD in the risk of BPH was insignificant (P = 0.208).
Conclusion: NAFLD is associated with an increased risk of BPH regardless of metabolic syndrome, especially in non-obese subjects. An incrementally increased risk of BPH according to NAFLD severity is prominent in non-obese subjects with NAFLD. Thus, physicians caring for non-obese patients with NAFLD may consider assessing the risk of BPH and associated urologic conditions.
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KEYWORD
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Hepatic Steatosis, Non-Obese, Prostate Hyperplasia
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