|
KMID : 0213520180320050417
|
|
Korean Journal of Ophthalmology
2018 Volume.32 No. 5 p.417 ~ p.423
|
|
|
Effective Delivery of Exogenous Compounds to the Optic Nerve by Intravitreal Injection of Liposome
|
|
Lee Jun-Sung
Goh Un-Byeol
Park Ji-Ho
Park Sang-Woo
Heo Hwan
|
|
|
Abstract
|
|
|
Purpose: To improve the treatment efficiency of optic nerve diseases by delivering therapeutic materials to the optic nerve directly.
Methods: We tried to optimize liposomal composition to deliver a payload to the optic nerve efficiently when it is injected intravitreally. After loading dexamethasone into this liposome, we tested the therapeutic effect of liposomes in this treatment using a murine model of ischemic optic neuropathy.
Results: Our optimized liposome can deliver its payload to the optic nerve more efficiently than other tested compositions. Moreover, dexamethasone-loaded liposomes had a significant therapeutic effect in a murine model of ischemic optic neuropathy.
Conclusions: Here, we demonstrate the optimal composition of liposomes that could efficiently deliver intravitreally injected exogenous compounds to the optic nerve. We expect that the intravitreal injection of liposomes with the suggested composition would improve the delivery efficacy of therapeutic compounds to the optic nerve.
|
|
|
KEYWORD
|
|
|
Drug delivery, Liposomes, Optic nerve, Optic nerve diseases
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|