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KMID : 0213520190330030279
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Korean Journal of Ophthalmology
2019 Volume.33 No. 3 p.279 ~ p.286
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Spatial and Temporal Characteristics of Visual Field Progression in Glaucoma Assessed by Parallel Factor Analysis
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Kim Seung-Mo
Shon Kil-Hwan
Sung Kyung-Rim
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Abstract
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Purpose: To explore spatial and temporal characteristics of glaucomatous visual field (VF) progression through multi-way decomposition of data.
Methods: Six serial VF exams with intervals of 6.0 ± 1.0 months in 121 pre-perimetric glaucoma eyes and 80 perimetric glaucoma eyes were arranged into a three-dimensional cube. The data were decomposed using parallel factor analysis.
Results: Three tri-linear components (i.e., spatial scores, temporal loadings, and subject-specific loadings) were identified. Component 1 clearly showed differences between superior and inferior hemispheres, linear trends over time, and wide variability in perimetric glaucoma. Findings were compatible with well-known characteristics of glaucomatous VF defects. Component 2 showed nasal and central areas in contrast with superior, inferior, and temporal peripheral locations, whereas component 3 showed a contrast between nasal and temporal hemispheres. Both components 2 and 3 failed to show clear temporal trends.
Conclusions: Identification of spatio-temporal patterns shows new possibilities for a multi-way decomposition methodology for earlier diagnosis and prediction of glaucomatous VF progression.
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KEYWORD
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Glaucoma, Multi-way decomposition, Parallel factor analysis, Visual fields
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