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KMID : 0350519940470031193
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Journal of Catholic Medical College
1994 Volume.47 No. 3 p.1193 ~ p.1203
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The Effect of Hyaluronic Acid on the Articular Cartilage of Methylprednisolone Induced Degenerative Arthritis in Rabbit Knee
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Abstract
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Hyaluronic acid is the most abundant component in synovial fluid. This liquid acts as a lubricants and a source of nutrients of articular cartilage. Hyaluronic acid also plays a structural role in chondrocytes through proteoglycan retention at
the
cell
surface.
The purpose of this study is to observe the steroid induced degenerative changes of articular cartilage and the effects of hyaluronic acid on it in rabbit knees.
Hyaluronic acid group(20 rabbits) received intraarticular methylprednisolone injection to their left knees once a week for six weeks which was followed by intraarticular injection of hyaluroniccid once week for six weeks.
Steriod group(20 rabbits) received intraarticular methylprednisolone injection to their left knees once a week for six weeks.
Control group(6 rabbits) received intraarticular normal saline injection to their left knees once a week for 12 weeks.
The articular cartilage of all groups were observed grossly, histologically, histochemically, and scanning electron microscopically at 10th and 14th weeks.
@ES The results are as follows:
@EN 1. Grossly, there were degenerative changes of articular cartilage in hyaluronic acid group & steroid group. These degenerative changes were less severe in hyaluronic acid group.
2. In microscopic examination, degenerative changes of chondrocytes and cartilage layer were observed in hyaluronic acid group & steroid group. These changes were less severe in hyaluronic acid group.
3. Safranin-O histochemical staining showed decreased stainability in hyaluronic acid group & steroid group compared with control group. These decreased stainability were less severe in hyaluronic acid group.
4. In histologic grading system(Williams et al., 1993), there were less significant degenerative changes in steroid group than hyaluronic acid group.
5. In scanning electron microscope, significant degenerative changes were found in hyaluronic acid group & steroid group compared with control group, and the changes were less severe in hyaluronic acid group.
Above mentioned results showed the possibility of regenerative effects of hyaluronic acid on steroid induced degenerative arthritis.
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