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KMID : 0350519940470031245
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Journal of Catholic Medical College
1994 Volume.47 No. 3 p.1245 ~ p.1253
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The Effect of Propranolo on Hemodynamics, Plasma Renin Activity and Catecholamine during Nitroglycerin-induced Hypotension in Rabbit
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Abstract
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Nitroglycerin(NTG) was used for inducing hypotension in this study. It is safer than sodium nitroprusside and induces hypotension by direct relaxation of vascular smooth muscle.
Propranolol, nonselective β-adrenergic blocking agent, was used for the pretreatment, 10 minutes before NTG infusion.
This study was performed to investigate the effect of propranolol, β-adrenergic blocker, on hemodynamic changes, plasma renin activity(PRA) and catecholamines during nitroglycerin-induced hypotension.
For this study 16 rabbits were used, which were divided into two groups.
Control group(8 rabbits) was infused with NTG only at the rate of 30 μg/kg/min. Propranolol group(8 rabbits) was pretreated with propranolol 1mg/kg, 10 minutes before NTG infusion.
@ES The results were as follows:
@EN 1) The mean arterial pressure of the propranolol group was decreased under 60 mmHg. However, mean arterial pressure of the control group was not decreased under 60 mmHg.
2) The heart rate was not significantly changed after NTG infusion in each group.
But the heart rate in the propranolol group was lower than that in the control group.
3) Plasma renin activity was significantly increased as MAP decreased after NTG infusion in each group. But PRA in the propranolol group was significantly suppressed at 10 minutes after NTG infusion.
4) Epinephrine and Norepinephrine were significantly increased as MAP decreased after NTG infusion.
Epinephrine in the propranolol group was significantly supressed.
Norepinephrine in that group was suppressed also, but stastistically insignificant.
Propranolol premedication suppressed the renin release and attenuated the stress response during nitroglycerin induced hypotension.
Therefore, we could induce desirable hypotension under 60 mmHg in this study.
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