|
KMID : 0350519940470031285
|
|
Journal of Catholic Medical College
1994 Volume.47 No. 3 p.1285 ~ p.1294
|
|
|
Change of Plasma Motilin Concentration in Neonatal Period According to Gestational Age and the Effect of Enteral Nutrition
|
|
|
|
|
Abstract
|
|
|
Nutriotion is very important for the better care of the preterm neonate. During the postnatal period, major changes occur in gastrointestinal structure, motility, digestive and absorptive function.
It has been known that enteral feeding and gastrointestinal hormones influence the postnatal nutritional adaptation in preterm babiels.
Motilin is one of the most important peptides which regulate motor function of gastrointestinal tract.
To investigate the change of plasma motilin concentrations according to gestational age and the effect of enteral feeding on this change in neonatal pereiod, authors analyzed the plasma motilin concentrations of preenteral nutritional state, pre
and
postprandial states at 6th day of enteral nutrtion from 60 babies. Gut transit time was checked in 27 babies and compared between term and preterm groups.
Plasma motilin concentration was measured by radioimmunoassay modified from method of Dryburgh and Brown(1975).
@ES The results were as follows;
@EN 1. Before start of enteral nutrition, the mean plasma motilin concentration(pmol/L) of 31-32 weeks(I) group, 33-34 weeks(Ⅱ) group, 35-36 weeks(Ⅲ) group and avove 37 weeks(Ⅳ) group were 27.4±2.4, 27.0±2.7, 27.7±2.1 and
37.1±3.7respectively.
There was no significant difference. of mean plasma motilin concentration in group I , Ⅱ and Ⅲ, but that of group Ⅳwas higher than that of others(P<0.05).
2. The mean plasma motilin concentration(pmol/L) of preprandial at 6th day of enteral feeding of group I, Ⅱ, Ⅲ and Ⅳwere 49.1±5.9, 45.3±4.8, 33.1±3.2 and 45.3±6.8 respectively. There was no significant difference between each group. That
of
1
hour postprandial were 37.5±4.7(I), 33.7±4.3(ii), 25.6±3.6(iii) and 35.1±5.1(Ⅳ). The mean plasma motilin concentration of postprandial decreased from preprandial concentration significantly(P,0.05, respectively) in all groups.
3. The preprandial mean plasma motilin concentration at 6th day of enteral nutrition in each group increased from that of preenteral nutrition. This tendency was more prominent in group I and group ii(P<0.05).
4. The mean plasma motilin concentration(pmol/L) of preprandial at 2 weeks later of group I was 70.1±12.1 and this concentration is higher than that of group ii preenteral nutrition state(P<0.05). The mean plasma motilin concentration of
preprandial
at 2 weeks later of group iii was 44.8±7.7 and this concentration is slinghtly higher than that of group Ⅳpreenteral nutrition state.
From these results, it is suggested that the plasma motilin concentration of preenteral nutrition in term neonate is higher than that of preterm neonate and there is no change of concentration from 31 to 36 weeks of gestation. But enteral
nutrition
abolishes the difference between term and preterm babies even in early 31 weeks of gestation. So early enteral nutrition should be encouraged for the nutrition of small preterm babies above 31 weeks of gestation.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|