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KMID : 0350519950480010227
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Journal of Catholic Medical College
1995 Volume.48 No. 1 p.227 ~ p.234
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Interleukin-4 and Interleukin-7 in Middle Ear Effusion
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Abstract
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One of the most important factors influencing on the etiology and pathogenesis of otitis media with effusion seems to be retention of inflammatory cells and mediators.
Cytokines are potent regulators of the immune response and produced by macrophages, neutrophils, lymphocytes and other cells. The object of this study is to evaluate the presence and concen tration of both interleukin 4(IL-4) and interleukin
7(IL-7) in
the middle ear effusion using enzymelinked immunosorbent assay(ELISA). The study group included 18 patients with middle ear effusion who underwent placement of tympanostomy tube. Twenty-four middle ear effusions were collected from the 18
patient.
The
cases with detectable cytokine levels above the lowest standard value provided with the ELISA were considered as positive response in middle ear effusions(MEES).
@ES The results were as follows :
@EN 1. IL-4 was detected in 8(33.3%) of 24 of MEES. 2(18.2%0 of 11 serous type of MEES and 6(46.2%) of 13 mucoid type of MEES. IL-7 was detected in 9(47.4%) of 19 of MEES, 2(25.0%) of 8 serous type of MEES and 7(63.%) of 11 mucoid type of MEES.
2. The IL-4 levels found in ears with an effusion had an average of 9.64±2.13 pg/ml IgG for serous effustion and 29.55±22.14 pg/ml IgG for mucoid effusion respectively.
3. The IL-7 levels found in ears with an effusion had an average of 88.5±26.2 pg/ml IgG for serous effusion and 73.24±47.88 pg/ml IgG for mucoid effusion respectively.
The results suggest that IL-4 and IL-7 may be an important regulators of the local immune response in middle ear cleft during otitis media with effusion and may play an essential role in the development of otitis media.
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