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KMID : 0350519960490041267
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Journal of Catholic Medical College
1996 Volume.49 No. 4 p.1267 ~ p.1280
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Inhibitory Effect of CD18 Monoclonal Antibody and Superoxide Dismutase on Ischemia
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Abstract
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Tissue injury resulting from ischemia and reperfusion can worsen the results of reconstructive surgeries including free tissue transfer and replantation. Oxygen free radicals have enjoyed increasing popularity as a cause of reperfusion injury.
Current
studies in myocardium, liver, and intestine have shown a dramatic increase in tissue leukocytes after ischemia-reperfusion and evidence implicating leukocytes in pathogenesis of ischemia-reperfusion injury has come from studies demonstrating
significant
injury reduction by depletion of circulating neutrophils.
@ES The results were as follows:
@EN 1. The percentage of flap survival was significantly increased in CD18 mAb/SOD, CD18 mAb and SOD groups in that order when compared to the control (P<0.05). The percentage of flap survival was significantly increased in Cd18 mAb group
compared
with
SOD group (P<0.05). The percentage of flap survival significantly increased in CD18 mAb/SOD group compared with CD18 mAb and SOD group (P<0.05).
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KEYWORD
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