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KMID : 0352719920160010018
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Journal of Ginseng Research
1992 Volume.16 No. 1 p.18 ~ p.23
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Behaviorpharmacological Studies of Standardized Ginseng Extract G115 on the Central Dopaminergic Activity(I)
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Abstract
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Central dopaminergic activity of standardized ginseng extract G115 was investigated in comparison with those induced by haloperidol in rats. The effects of G115 on the locomotor activity and stereotyped behavior induced by apomorphine which
interacts
directly with dopamine receptor were observed. Apomorphine(2mg/kg) significantly decreased locomotor activity, whereas it showed a markdly increased incidence of stereotyped behavior, Standardized ginseng extract G115(100mg/kg) and
haloperidol(1mg/kg)showed a significant decrease in locomotor activity but not induced stereotyped hehavior. Locomoter activity induced by apomorphine was markdly decreased by haloperidol(1mg/kg), but that was significantly increased by
standardized
ginseng extract G115(50mg/kg). Stereotyped behavior induced by apomorphine was completely supressed haloperidol(1mg/kg).but was not changed by standardized ginseng extract G115, These results suggest that standardized ginseng extract G115 plays
an
impotant role in central dopaminergic activity and haloperidol and standardized ginseng extract G115 seem to have a different action in behavior.
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