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KMID : 0352720080320020150
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Journal of Ginseng Research
2008 Volume.32 No. 2 p.150 ~ p.154
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Scavenging Strategy of Panax ginseng Against Formed Free Radicals Under Stress of Mercuric Chloride in Rattus norvegicus
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Saxena Prabhu N.
Mahour Kanhiya
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Abstract
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Twenty five albino rats were divided into five groups for conducting this experiment. The first group was for positive control (Vitamin C, ascorbic acid), the second group was of Panax ginseng (10 mg/kg body weight) treated group after bio-activity assay, the third group was of mercuric chloride treated group (0.033 mg/kg body weight) based on calculating 9.26 mg/kg body weight by probit analysis, the fourth group was of mercuric chloride (0.033 mg/kg body weight) followed by Panax ginseng (10 mg/kg body weight) and the fifth group was Panax ginseng (10 mg/kg body weight) followed by mercuric chloride (0.033 mg/kg body weight) treated group. The interval between intake of Panax ginseng and mercuric chloride was of 2 hours in groups, fourth and fifth respectively. Comparative free radical scavenging property of Panax ginseng was studied under three in vitro models (role model for calculating scavenging activity) viz. DPPH method (hydroxyl free radicals), Nitric oxide method (nitrile free radicals) and Lipid peroxidation (mercury free radicals).
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KEYWORD
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Ascorbic acid, 1, 1 diphenyl 2-picryl hydrizide, thiobarbituric acid reactive substances, lipid peroxidation
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