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KMID : 0352720100340040363
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Journal of Ginseng Research
2010 Volume.34 No. 4 p.363 ~ p.368
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Inhibitory Effects of Ginsenoside Rb₁ on Atopic Dermatitis-Like Skin Lesions in Mice
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Park Hye-Jin
Byeon Hye-Eun
Choi Ku-Woon
Rhee Dong-Kwon
Lee Kang-Ro
Pyo Suhk-Neung
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Abstract
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Allergies are immediate hypersensitive responses to antigens and interleukin (IL)-4 is involved in the initiation and development of allergic responses. Rb₁ has been known to have a variety of biological activities including anti-inflammatory activity, but the effect of Rb₁ on allergic responses is not known yet. The present study was undertaken to examine whether Rb₁ has an inhibitory effect on allergic response in mouse model. In allergic mouse model, our results showed that topical application of Rb₁ on atopic dermatitis (AD)-like skin lesions improved skin condition and inhibited starching behaviors. In addition, Rb₁ application not only suppressed mRNA expression of IL-4 and IL-10, but also prevented the nuclear factor of activated T cells 1 transcription. Moreover, Rb₁ application suppressed IL-4’ secretion. Taken together, these results suggest that Rb₁ has a potent inhibitory effect in AD-related T cell cytokine production and may be a candidate for therapeutic agent in allergy.
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KEYWORD
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Ginsenoside Rb₁, Atopic dermatitis, Scratching behaviors, Interleukin-4
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