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KMID : 0352720160400040344
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Journal of Ginseng Research
2016 Volume.40 No. 4 p.344 ~ p.350
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In vitro and in vivo evaluation of tissue-cultured mountain ginseng on penile erection
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Lee Ho-Sung
Lee Young-Joo
Chung Yoon-Hee
Lee Moo-Yeol
Kim Sung-Tae
Ko Sung-Kwon
Mariko Momoi
Yutaka Kondoh
Fumio Sasaki
Jeong Ji-Hoon
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Abstract
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Background: Progressed tissue culture techniques have allowed us to easily obtain mass products of tissue-cultured mountain ginseng over 100 yr old (TCMG-100). We investigated the effects of TCMG-100 extract on erectile function using in vitro and in vivo studies.
Methods: To examine the relaxation effects and mechanisms of action of TCMG-100 on rabbit cavernosal strips evaluated in an organ bath. To investigate the long-term treatment effect of TCMG-100, 8-wk administration was performed. After administration of TCMG-100, intracavernosal pressure, cyclic guanosine monophosphate and nitric oxide (NO) levels of cavernosal tissue, serum testosterone level, histological observation of collagen fiber, endothelium, smooth muscle cell, and transforming growth factorb1 were investigated.
Results: TCMG-100 extract displayed dose-dependent relaxation effects on precontracted rabbit corporal smooth muscle. The TCMG-100-induced relaxation was significantly reduced by removing the endothelium, and treatment with an NO synthase inhibitor or NO scavenger. Eight weeks of TCMG-100 administration increased intracavernosal pressure in a rat model. The levels of cyclic guanosine monophosphate and NO in the corpus callosum and serum testosterone level were also increased by TCMG- 100 treatment. Furthermore, histological evaluation of collagen, smooth muscle, and endothelium showed increases in endothelium and smooth muscle, and a decrease in transforming growth factor-b1 expression.
Conclusion: These relaxation effects on corporal smooth muscle and increased erectile function suggest that TCMG-100 might be used as an alternative herbal medicine to improve erectile function.
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KEYWORD
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corpus cavernosum, erectile function, mountain ginseng, nitric oxide, smooth muscle
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