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KMID : 0352720180420030298
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Journal of Ginseng Research
2018 Volume.42 No. 3 p.298 ~ p.303
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Ginsenoside Rg1 modulates medial prefrontal cortical firing and suppresses the hippocampo-medial prefrontal cortical long-term potentiation
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Ghaeminia Mehdy
Rajkumar Ramamoorthy
Koh Hwee-Ling
Dawe Gavin S.
Tan Chay Hoon
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Abstract
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Background: Panax ginseng is one of the most commonly used medicinal herbs worldwide for a variety of therapeutic properties including neurocognitive effects. Ginsenoside Rg1 is one of the most abundant active chemical constituents of this herb with known neuroprotective, anxiolytic, and cognition improving effects.
Methods: We investigated the effects of Rg1 on the medial prefrontal cortex (mPFC), a key brain region involved in cognition, information processing, working memory, and decision making. In this study, the effects of systemic administration of Rg1 (1 mg/kg, 3 mg/kg, or 10 mg/kg) on (1) spontaneous firing of the medial prefrontal cortical neurons and (2) long-term potentiation (LTP) in the hippocampal?medial prefrontal cortical (HP?mPFC) pathway were investigated in male Sprague?Dawley rats.
Results: The spontaneous neuronal activity of approximately 50% the recorded pyramidal cells in the mPFC was suppressed by Rg1. In addition, Rg1 attenuated LTP in the HP?mPFC pathway. These effects were not dose-dependent.
Conclusion: This report suggests that acute treatment of Rg1 impairs LTP in the HP?mPFC pathway, perhaps by suppressing the firing of a subset of mPFC neurons that may contribute to the neurocognitive effects of Rg1.
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KEYWORD
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ginsenoside Rg1, hippocampus, long-term potentiation, medical prefrontal cortex, single unit
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