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KMID : 0352720180420040436
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Journal of Ginseng Research
2018 Volume.42 No. 4 p.436 ~ p.446
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Korean Red Ginseng mitigates spinal demyelination in a model of acute multiple sclerosis by downregulating p38 mitogen-activated protein kinase and nuclear factor-kB signaling pathways
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Lee Min-Jung
Chang Byung-joon
Oh Sei-Kwan
Nah Seung-Yeol
Cho Ik-Hyun
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Abstract
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Background: The potential therapeutic values of Korean Red Ginseng extract (KRGE) in autoimmune disorders of nervous system have not been fully investigated.
Methods: We used an acute experimental autoimmune encephalomyelitis animal model of multiple sclerosis and determined the effects and mechanism of KRGE on spinal myelination.
Results: Pretreatment with KRGE (100 mg/kg, orally) for 10 days before immunization with myelin basic protein (MBP)68e82 peptide exerted a protective effect against demyelination in the spinal cord, with inhibited recruitment and activation of immune cells including microglia, decreased mRNA expression of detrimental inflammatory mediators (interleukin-6, interferon-g, and cyclooxygenase-2), but increased mRNA expression of protective inflammatory mediators (insulin-like growth factor b1, transforming growth factor b, and vascular endothelial growth factor-1). These results were associated with significant downregulation of p38 mitogen-activated protein kinase and nuclear factor-kB signaling pathways in microglia/macrophages, T cells, and astrocytes.
Conclusion: Our findings suggest that KRGE alleviates spinal demyelination in acute experimental autoimmune encephalomyelitis through inhibiting the activation of the p38 mitogen-activated protein kinase/nuclear factor-kB signaling pathway. Therefore, KRGE might be used as a new therapeutic for autoimmune disorders such as multiple sclerosis, although further investigation is needed.
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KEYWORD
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demyelination, experimental autoimmune encephalomyelitis, Korean Red Ginseng, nuclear factor-kB, p-38 mitogen-activated protein kinase
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