KMID : 0356719980140030655
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Journal of the Korean Society of Coloproctology 1998 Volume.14 No. 3 p.655 ~ p.659
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Small Flat Adenocarcinoma of the Colon Arising from Familial Adenomatous Polyposis Patient: Suggesting de novo Origin
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Park Dong-Kook
Lee Min-Chul Jun Ho-Jin Lee Chan-Young Kim Jung-Teak Jung Min Park Jong-Kweon Ryu Jin-Woo
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Abstract
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Most adenocarcinomas of the colorectum arise in a visible benign precursor lesion, the adenoma, which is a monoclonal proliferation of dysplastic nonmalignant epithelial cells. Adenoma-adenocarcinoma sequence has been represented as the predominat pathogenetic pathway. But a small flat depressed colon cancer is characterized by non-polypoid growth pattem with no association of adenomatous tissues, which has tendency to early submucosal invasion and lymph node metastasis even in very small lesion (<10 mm). It supports de novo carcinogenesis of colorectal cancer, although most colorectal cancerarise in pre-existing adenoma. We report a case of small float colon adenocarcinoma arising in normal colonic epithelium rather than adenomatous polyp in familial adenomatous polyposis syndrome.
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KEYWORD
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Small flat adenocarcinoma, Colon
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