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KMID : 0356720040200060391
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Journal of the Korean Society of Coloproctology
2004 Volume.20 No. 6 p.391 ~ p.398
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Expression of β-catenin in Colorectal Cancer with Liver Metastasis
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Han Sang-Ah
Park Chi-Min
Kang Shin-Jea
Song Sang-Yong
Kim Sang-Hee
Son Dae-Soon
Yun Seong-Hyeon
Lee Woo-Yong
Chun Ho-Kyung
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Abstract
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Purpose: Decreased expression of β-catenin has been known to be associated with tumor metastasis. However, the clinical relationship between the degree of expression and the prognosis in colorectal cancer (CRC) remains unclear. In this study, we evaluated the prognostic value of β-catenin expression in CRC patients with liver metastasis.
Methods: Paraffin embedded blocks were obtained from 70 patients who underwent potentially curative resection for CRC with liver metastasis. Samples from normal colon mucosa, primary CRC and metastatic liver lesion were prepared in tissue microarrays and were stained by immunohistochemistry with monoclonal antibody against β- catenin. The membranous β-catenin expression was assessed and the β-catenin expression difference between primary CRC and metastatic liver lesion was analysed in relation to overall survival as well as disease free survival rates.
Results: In β-catenin expression, preserved expression (score ＞6) was observed in 42.0%, and 21.9% of primary CRC tumor samples and tumor samples from metastatic liver lesion respectively. The degree of β-catenin expression in metastatic liver lesion was significantly lower than that in primary CRC (P=0.022).According to the difference of β-catenin expression score between primary CRC and liver metastasis, patients were classified as group ´A´ and ´B´. Group ´A´ was defined as patients showing remarkably decreased expression of β-catenin in metastatic liver lesion in that the difference of the score was three or more. Group ´B´ was defined as patients showing maintained or increased β-catenin expression in metastatic liver lesion in comparison to primary CRC, in that the difference of β-catenin expression score was less than three. Overall survival rate and disease free survival rate were significantly better in group ´B´ than group ´A´ (P=0.02, P=0.002).
Conclusions: Decreased expression of β-catenin in metastatic liver lesion may be a poor prognostic marker in colorectal cancers with liver metastasis. A further large-scaled investigation is necessary to define the role of β-catenin in CRC. J Korean Soc Coloproctol 2004;20:391-398
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KEYWORD
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Beta-catenin, Colorectal neoplasm, Metastatic liver lesion, Tissue microarray, Immunohistochemistry
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