|
KMID : 0356720070230010034
|
|
Journal of the Korean Society of Coloproctology
2007 Volume.23 No. 1 p.34 ~ p.40
|
|
|
Prognostic Significance of p27kip1 Expression in Node Negative Colorectal Carcinoma
|
|
Song Sang-Hyun
Bae Byung-Noe
Lee Woo-Yong
Yang Keun-Ho
Kim Ki-Hwan
Han Se-Hwan
Kim Hong-Ju
Kim Young-Duk
Kim Hong-Yong
Kim Jung-Yeon
|
|
|
Abstract
|
|
|
Purpose: Dukes’ A & B colorectal cancer patients are often excluded from adjuvant chemotherapy following potentially curative surgery because they are expected to have good long-term survival. However, actually 20∼30% of these patients suffer from recurrent disease, so it would be helpful for these patients of recurrent disease to be able to select a high risk group.
Methods: In 78 Dukes’ A & B colorectal cancers, we investigated by immunohistochemistry the role of molecular markers, such as p27kip1, p53, Ki-67, and Skp2, in identifying high-risk patients.
Results: Patients with low p27kip1 expression showed poor overall survival compared to those with high p27kip1 expressions (55.3 versus 66.7 months, P=0.018). The only significant factor associated with p27kip1 expression was p53 expression. The low p27kip1 expression and positive p53 expression group had poor overall survival (54.3 months, P=0.036).
Conclusion: In a node-negative colorectal carcinoma, the molecular marker p27kip1 does not play an independent prognostic role, but it may have prognostic significance in correlation with other markers such as p53, Ki-67, and Skp2. The assessment of molecular alterations may be useful to node-negative colorectal patients in identifying the high risk group that may benefit from adjuvant chemotherapy. J Korean Soc Coloproctol 2007;23:34-40
|
|
|
KEYWORD
|
|
|
Colorectal cancer, p27kip1, Skp2, Prognosis
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|
|