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KMID : 0356820070230020153
Korean Journal of Head & Neck Oncology
2007 Volume.23 No. 2 p.153 ~ p.156
A Case of Pharmacokinetics of Cisplatin in Concurrent Chemoradiation for Hemodialysis Patient with Advanced Head and Neck Cancer
Chun Yeon-Joo

Shim Byoung-Yong
Kim Hyung-Wook
Lee Sang-Hun
Lee Ho-Sang
Park Cheol-Whee
Kim Su-Zy
Kuh Hyo-jeong
Kim Hoon-Kyo
Abstract
Objective : We study the feasibility and pharmacokinetics of cisplatin concurrent chemoradiation for advanced head and neck cancer patient undergoing hemodialysis.

Materials & Methods : A 57-year old male with end stage renal disease developed stage III external auditory canal cancer. Complete resection surgery was done. Postoperative 6 months, local recurrence was occurred. Despite excision and adjuvant radiotherapy, local tumor was recurred. We decided to treat a cisplatin concurrent chemoradiotherapy. Cisplatin was administered at a dose of 20mg/m^2 for 30 min. Hemodialysis was started 30 min after completion of the cisplatin infusion and performed for 4 hours. Hemodialysis was performed on day 3 and 5 of chemotherapy. Plasma samples were collected at specified times after administration of cisplatin.

Results : At the end of the third cycle of cisplatin concurrent chemoradiotherapy, the tumor size was markedly decreased. The maximum plasma concentrations of plasma platinum and free platinum were 0.74 and 0.37{mu}g/ml respectively. The area under the curve of plasma platinum and free platinum were 94.7 and 11.3{mu}g{cdot}h/ml respectively.

Conclusion : We report a case of Cisplatin concurrent chemoradiation for hemodialysis patient with advanced head and neck cancer and suggest full dose cisplatin concurrent chemoradiotherpay is tolerable for these patients.
KEYWORD
Pharmacokinetics, Cisplatin, Head and neck cancer, Hemodialysis
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