KMID : 0357419950250020181
|
|
Korean journal of Virology 1995 Volume.25 No. 2 p.181 ~ p.188
|
|
The Change of Intracellular pH following Infection with Human Cytomegalovirus
|
|
|
|
Abstract
|
|
|
Infection of human embroy lung (HEL)cells with human cytomegalovirus (HCMV) resulted in change of intracellular pH([pH]i). A maximal increase in [pH]i was observed at 12 hr postinfection (p.i.) in HCMV-infected HEL cells. Inactivation of HCMV
with
heat
treatment or UV irradiation effectively abolished the HCMV-induced increase in [pH]i observed at 12 hr p.i. in HEL cells. And the degree of the increase in [pH]i was dependent on the amount of infectious virus. Treatment of HCMV-infected HEL
cells
with
amiloride, an inhibitor of Na+/H+ exchanger, partially blocked the increase in [pH]i. These results suggest a possible relationship between the change of intracellular pH and HCMV replication.
|
|
KEYWORD
|
|
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|