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KMID : 0358820100370020105
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Journal of Korean Society of Plastic and Reconstructive Surgeons
2010 Volume.37 No. 2 p.105 ~ p.110
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Effect of Platelet-rich Plasma (PRP) on Regeneration of Rat Sciatic Nerve in a Silicone Chamber
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Minn Kyung-Won
Jeong Eui-Cheol
Chang Hak
Kwon Sung-Tack
Kim Suk-Wha
Baek Rong-Min
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Abstract
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Purpose: The purpose of this study is to determine the effect of platelet-rich plasma (PRP) on rat sciatic nerve regeneration in a 10 mm silicone chamber.
Methods: A total of 6 inbred Lewis rats were used in this study. Bilateral sciatic neurectomy was performed on each rat. On one side, silicone chambers containing PRP solutions were implanted; on the contralateral side, the chambers without PRP were implanted as a control. In 12 weeks post-implantation, chambers were retrieved and both gastrocnemius muscles were excised. Nerves biopsy samples were examined under a light microscope after Masson trichrome staining.
Results: Cross sections of the midpoints of PRP treated nerves were significantly larger and appeared more mature than those of controls.
Conclusion: Based on morphological evidence, PRP has a positive effect on neural regeneration, and it may therefore be useful for treating peripheral nerve injuries.
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KEYWORD
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Nerve regeneration, Platelet-rich plasma, Sciatic nerve, Entubulation
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