Sprague-Dawley rats received subcutaneous injections of gentamicin sulfate, 50 and 100㎎/㎏ for 3, 7 and 10 days. The hematological and blood chemical values were determined. Kidneys were examined histologically and ultrastructurally.
The results obtained were summarized as follows;
1. The serum values of aspartate transaminase, blood urea nitrogen and creatinine in the rats administered gentamicin, 50 and 100㎎/㎏/day were significantly increased than those in the control.
2. The ratio of kidney weight to body weight was significantly increased in the rats injected gentamicin, 100㎎/㎏ for 10 days than those in the control.
3. The brush borders of proximal convoluted tubules in the kindneys received gentamicin, 50 and 100㎎/㎏/day were decreased or absent in periodic acid-Schiff staining.
4. The necrosis of proximal convoluted tubules was shown in the rats given gentamicin, 50 and 100㎎/㎏ for 7 and 10 days.
5. The regeneration of the proximal tubular epithelia was observed in the rats treated gentamicin, 100㎎/㎏ for 10 days.
6. The number and size of lysosomes were increased in the proximal convoluted tubules of the rats injected gentamicin, 50㎎/㎏ for 7 days, many of which contained myeloid bodies.
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