KMID : 0359320030430040573
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Korean Journal of Veterinary Research 2003 Volume.43 No. 4 p.573 ~ p.578
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Mechanism of vasodilatation induced by substance P in isolated rabbit renal artery
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Kim, Joo-heon/±èÁÖÇå
Jeon, Seok-cheol/Hong, Yonggeun/Àü¼®Ã¶/È«¿ë±Ù
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Abstract
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The effects of removing the endothelium on the vasodilatory response to substance P, calcitonin gene-related peptide (CGRP), and vasoactive intestinal peptide (VIP) was examined in the isolated rabbit renal artery. The vasodilator response to substance P (0.1 ¥ìM) was completely absent in vessels in which the endothelium had previously been removed. There was no significant difference in the vasodilatation produced in response to CGRP (0.1¥ìM), or VIP (0.1 ¥ìM) in the intact and removed-endothelium rabbit renal artery segments. L-NAME (100 ¥ìM) significantly reduced the vasodilatory response to substance P (0.1 ¥ìM). This inhibition was significantly attenuated when L-arginine (10 mM) was also present in the organ bath along with L-NAME (100 ¥ìM). Indomethacin (1 ¥ìM) did not significantly affect the vasodilatation produced in response to substance P (0.1 ¥ìM). The inhibitory effect of L-NAME (100 ¥ìM) and indomethacin (1 ¥ìM) on the vasodilatory response to substance P (0.1 ¥ìM) was not significantly different from that produced by L-NAME (100 ¥ìM) alone. This study indicates that substance P induced vasodilatation via an endothelium-dependent mechanism in the isolated rabbit renal artery. It also established that CGRP and VIP induced vasodilatation by an endothelium-independent mechanism and substance P-induced vasodilatation is at least partially via NO.
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