KMID : 0359720110290030224
|
|
Journal of the Korean Neurological Association 2011 Volume.29 No. 3 p.224 ~ p.226
|
|
Intrathecal Chemotherapy Related Myelopathy Improved with Folate and Cyanocobalamin
|
|
Park Su-Yeon
Park Hye-ri Kim Jee-Eun Sung Jung-Joon
|
|
Abstract
|
|
|
Intrathecal chemotherapy with methotrexate and cytarabine arabinoside is used for the treatment and prophylaxis of malignancies, but can induce myelopathy. We report the case of a 50-year-old woman with stomach cancer who developed myelopathy after administration of intrathecal cytarabine arabinoside and methotrexate. The patient¡¯s neurologic status improved rapidly after the administration of folinate (15 mg) four times daily and cyanocobalamin (100 ¥ìg) once daily. The folate metabolites may be effective in the management of intrathecal-chemotherapy-induced myelopathy.
|
|
KEYWORD
|
|
Intrathecal chemotherapy, Myelopathy, Folate metabolites
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|