KMID : 0360220220630080712
|
|
Journal of the Korean Ophthalmological Society 2022 Volume.63 No. 8 p.712 ~ p.716
|
|
A Case of Combination Therapy of IFN-¥â1b and Mitomycin-C on Recurred Ocular Surface Squamous Neoplasia
|
|
Lee Jun-Kyu
Son Bo-Kwon Jin Kyung-Hyun
|
|
Abstract
|
|
|
Purpose: To report a case of combination therapy with interferon ¥â1b (IFN-¥â1b) and mitomycin-C (MMC) for recurrent ocular surface squamous neoplasia (OSSN).
Case summary: A 72-year-old female presented with a white mass at the medial conjunctiva of the right eye. A gelatinous, nodular white lesion was observed near the medial limbus of the right eye. On histological examination, it was diagnosed as squamous cell carcinoma in situ. A white nodule was found at the resection site 1 year after the resection. IFN-¥â1b (1 mIU/mL) and 0.02% MMC were administered daily with a diagnosis of recurrent OSSN. IFN-¥â1b was instilled four times a day for 1 month, while MMC was instilled four times a day for 4 weeks. After 1 month of the combination treatment, the lesion disappeared. MMC was stopped, while IFN-¥â1b was reduced to twice daily instillation, maintained for 1 month, and then stopped. On examination 12 months after discontinuation of the combination treatment, there were no recurrences or drug-related complications.
Conclusions: Combination therapy with IFN-¥â1b and MMC for recurrent OSSN after surgical resection was relatively safe with no major complications.
|
|
KEYWORD
|
|
Combination therapy, Interferon beta-1b, Mitomycin-C, Ocular surface squamous neoplasia, Topical chemotherapy
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|