KMID : 0360220230640121183
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Journal of the Korean Ophthalmological Society 2023 Volume.64 No. 12 p.1183 ~ p.1190
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Association Between Tear Osmolarity and Dry Eye Signs in Patients with Obstructive Meibomian Gland Dysfunction
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Choi Han-Sol
Lee Si-Hyung
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Abstract
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Purpose: To explore the correlations between tear osmolarity, as measured using I-PEN¢ç (I-MED Pharma, Inc., Dollard-des-Ormeaux, QC, Canada), and various dry eye indicators, including the Schirmer test, tear break-up time (TBUT), Oxford scale, and Ocular Surface Disease Index (OSDI), in patients with obstructive meibomian gland dysfunction (MGD).
Methods: The medical records of 44 cases of obstructive MGD were reviewed. Tear osmolarity was obtained using I-PEN¢ç (I-MED Pharma, Inc.). The TBUT, Schirmer test, Oxford scale, OSDI, and MGD grade were used to assess the cases, and their correlations with tear osmolarity were analyzed.
Results: Spearman and Pearson correlation analyses showed a significant correlation between tear osmolarity and MGD grade (p < 0.001) and OSDI (p = 0.005). However, the results of the TBUT, Schirmer test, and Oxford scale were not significantly related to tear osmolarity. The patients were divided according to MGD severity into those with MGD grades ¡Â 2 and those with MGD grades ¡Ã 3. Tear osmolarity (p < 0.001) and OSDI (p = 0.014) showed significant differences between the two groups.
Conclusions: In patients with obstructive MGD, tear osmolarity, assessed using I-PEN¢ç (I-MED Pharma, Inc.), is significantly correlated with MGD grade and OSDI.
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KEYWORD
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Dry eye syndrome, Meibomian gland dysfunction, Ocular Surface Disease Index, Tear osmolarity
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