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KMID : 0363220220600020106
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Korean Journal of Dermatology
2022 Volume.60 No. 2 p.106 ~ p.110
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CD30＋ Large-Cell Transformation of Mycosis Fungoides Treated with Brentuximab Vedotin
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Shin Jun-Oh
Bae Kyung-Nam
Son Jin-Hwa
Shin Ki-Hyuk
Kim Hoon-Soo
Ko Hyun-Chang
Kim Moon-Bum
Kim Byung-Soo
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Abstract
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Large-cell transformation of mycosis fungoides (LCT-MF) is an advanced stage of primary cutaneous T-cell lymphoma with a poor prognosis. Therapeutic options for these patients are often limited, and so far, they are not promising. An 81-year-old woman with a previous history of mycosis fungoides presented with aggravation of generalized erythematous scaly patches and new onset of ulcerated tumor on the abdomen for 3 months. Histopathological examination revealed a dense dermal infiltrate composed of atypical large lymphocytes. Immunohistochemically, the tumor cells were positive for CD30 expression. A diagnosis of CD30＋ LCT-MF was established. She was intensively treated with methotrexate (1 month), acitretin (1 month), and rituximab with dose-modified cyclophosphamide, doxorubicin, and prednisone (1 cycle). Despite such treatments, the improvement was minimal. Subsequently, the patient was started on brentuximab vedotin, 1.8 mg/kg intravenously once every 3 weeks. She responded well to brentuximab therapy, and the skin lesions completely subsided within 12 weeks of treatment
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KEYWORD
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Cutaneous T-cell lymphoma, Mycosis fungoides
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