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KMID : 0363220220600090549
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Korean Journal of Dermatology
2022 Volume.60 No. 9 p.549 ~ p.558
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Correlation between the Peripheral Eosinophil Count and Disease Severity in Patients with Bullous Pemphigoid: A Retrospective 20-Year Single-Center Study
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Kwon Hyeok-Jin
Yoon Jung-Ho
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Abstract
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Background: Bullous pemphigoid (BP) is an autoimmune blistering disease. Studies have focused on eosinophils fortheir significant role in the pathogenesis of BP, as they not only secrete proteases and proinflammatory cytokines butalso recruit other inflammatory cells.
Objective: To investigate the correlation among peripheral eosinophil count, clinical severity, and laboratory findingsin patients with BP.
Methods: A total of 59 patients with BP were included in this study. Correlation analyses between peripheraleosinophil count and bullous pemphigoid disease activity index (BPDAI) score, duration of hospitalization,anti-bullous pemphigoid antigen 180 (anti-BP180) immunoglobulin G (IgG) antibody, anti-bullous pemphigoidantigen 230 (anti-BP230) IgG antibody, immunoglobulin E (IgE), C-reactive protein, and procalcitonin levels wereperformed. Simple and multiple linear regression analyses were conducted to evaluate whether peripheral eosinophilcounts could independently affect the BPDAI score and hospitalization duration.
Results: The peripheral eosinophil count was positively correlated with the initial skin, mucosa, total BPDAI score(p＜
0.001, p=0.027, and p＜0.001, respectively), hospitalization days (p=0.032), anti-BP180 IgG antibody (p＜0.001), anti-BP230 IgG antibody (p＜0.001), and IgE (p＜0.001). Furthermore, not only peripheral eosinophilcount but also anti-BP180 IgG antibody, anti-BP230 IgG antibody, and IgE levels independently affected both theinitial total BPDAI score (p＜0.05) and hospitalization duration (p＜0.05).
Conclusion: Based on our results, the peripheral eosinophil count can influence both clinical severity and laboratoryfindings. Additionally, it can indicate the clinical severity and prognosis of BP. Therefore, we suggest that theperipheral eosinophil count could be a useful marker for predicting clinical outcomes in patients with BP.
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KEYWORD
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Autoantibody, Bullous pemphigoid, Cytokines, Eosinophils, Immunoglobulins
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