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KMID : 0363220220600090606
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Korean Journal of Dermatology
2022 Volume.60 No. 9 p.606 ~ p.610
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A Case of Generalized Granuloma Annulare Development in a Psoriasis Patient Treated with Interleukin-12/23 Blockers J
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Kim Jong-Wook
Jang Bong-Seok
Kim Yeon-A
Won Sang-Hyeon
Bae Kyung-Nam
Lee Jung-Soo
Shin Ki-Hyuk
Kim Hoon-Soo
Ko Hyun-Chang
Kim Moon-Bum
Kim Byung-Soo
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Abstract
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Granuloma annulare is a relatively common inflammatory skin disease. The etiology is unknown; however, drugshave been considered as one of the predisposing conditions, and a few cases of granuloma annulare related to biologics have been recently reported. A 48-year-old man with a 25-year history of psoriasis visited our dermatologicalclinic. Ustekinumab was administered for the treatment of psoriasis. After 5 years of ustekinumab therapy, erythematous papules with an annular distribution appeared on his trunk and extremities. Skin biopsy supported thediagnosis of generalized granuloma annulare, and the patient continued to receive ustekinumab with oral methotrexate, cyclosporine, and steroids for 9 months. However, as the skin lesions aggravated, oral steroid treatment wascontinued, and secukinumab was administered instead of ustekinumab. The skin lesions improved and remainedstable with the intermittent administration of oral steroids thereafter.
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KEYWORD
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Biological products, Granuloma annulare, Psoriasis, Ustekinumab
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