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KMID : 0363220220600090615
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Korean Journal of Dermatology
2022 Volume.60 No. 9 p.615 ~ p.617
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Successful Treatment of Palmoplantar Arsenical Keratosis with a Combination of Alitretinoin and Cryotherapy
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Lim Ji-Hoon
Lew Bark-Lynn
Sim Woo-Young
Kwon Soon-Hyo
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Abstract
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Chronic arsenic exposure causes varied dermatological sequelae, from arsenical keratosis to skin cancers. We reportthe successful treatment of palmoplantar arsenical keratosis with a combination of systemic alitretinoin and cryotherapy. A 49-year-old Korean man with a history of taking a traditional medicine formulation for 6 months in his early 30swas diagnosed with multiple cutaneous squamous carcinomas with metastasis to lymph node, squamous carcinomain situ, and palmoplantar arsenical keratosis. Wide local excision followed by adjuvant radiotherapy was done for themalignancies, and palmoplantar arsenical keratosis was treated with systemic alitretinoin (30 mg/d) and cryotherapy. Thepatient tolerated the treatment well, and arsenical keratosis was nearly cleared after 18 months.
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KEYWORD
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Alitretinoin, Arsenical keratosis, Cryotherapy, Squamous cell carcinoma
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