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KMID : 0363220220600100657
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Korean Journal of Dermatology
2022 Volume.60 No. 10 p.657 ~ p.665
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Immunohistochemical Expression of Yes-Associated Protein in Koreans with Acral Melanomas
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Kim Seung-Mee
Kim Do-Yeon
Kwon In-Sun
Shin Jeong-Min
Hong Dong-Kyun
Jung Kyung-Eun
Kim Chang-Deok
Lee Young
Seo Young-Joon
Park Sang-Hyun
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Abstract
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Background: Acral melanoma is the most common subtype of melanoma among Koreans, and regional or distantmetastasis is an indicator of poor prognosis. Yes-associated protein (YAP), a key effector of the Hippo pathway, isknown to induce tumor progression and metastasis in various cancers.
Objective: We aimed to analyze the clinical and histopathological characteristics of acral melanoma among Koreansand to evaluate their association with YAP expression.
Methods: This retrospective review included 27 patients with acral melanoma. Clinical features including age, sex, lesionsite, and stage were obtained from the medical records and images. Biopsy slides of patients with acral melanoma werereviewed, and immunohistochemical staining for YAP was performed.
Results: The rate of YAP expression was significantly higher in patients having acral melanoma with regional ordistant lymph node (LN) metastasis than in those without metastasis (n=4/5, 80.0% vs. n=2/22, 9.1%; p=0.004). Histopathologically,the rate of YAP expression was higher in patients having acral melanoma with lymphovascularinvasion than in those without lymphovascular invasion (n=4/8, 50.0% vs. n=2/19, 10.5%; p=0.044). Among the 27lesions, 14 (51.9%) were on stress-bearing sites such as the forefoot and heel. However, the rate of YAP expressiondid not differ significantly between weight-bearing and non-weight-bearing locations (p=0.834).
Conclusion: YAP expression is significantly associated with metastasis, especially LN metastasis, in patients with acralmelanoma. Therefore, YAP expression may be used as a prognostic factor for LN metastasis and a target for noveltreatments in patients with melanoma.
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KEYWORD
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Acral melanoma, Lymph node metastasis, YAP
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