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KMID : 0363220220600100679
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Korean Journal of Dermatology
2022 Volume.60 No. 10 p.679 ~ p.682
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A Case of Rebound Phenomenon after Cessation of Cyclosporine for Guselkumab Therapy in Psoriasis
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Park So-Hee
Jung So-Young
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Abstract
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Cyclosporine is one of the main therapeutic agents for psoriasis. It is known that psoriasis relapses 2∼3 monthsafter discontinuation of cyclosporine, and exacerbation due to abrupt discontinuation of cyclosporine is uncommon.
We report a case of psoriasis that was aggravated by cyclosporine cessation for guselkumab treatment, but improvedwith continuous administration of guselkumab. A 55-year-old man with a history of psoriasis presented witherythematous scaly plaques on the whole body. He had been treated with cyclosporine for 18 months and hadreceived a subcutaneous injection of guselkumab 1 month previously. Two weeks after the first injection, the patientexperienced exacerbation of the lesions. Considering the aggravation caused by abrupt discontinuation ofcyclosporine, guselkumab administration was continued. The aggravated psoriatic lesions improved after additionalguselkumab injections. At 16 weeks, the Psoriasis Area and Severity Index score was 0, which remained constantthereafter.
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KEYWORD
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Biological products, Cyclosporine, Guselkumab, Psoriasis
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